posted by [identity profile] wonapalei.livejournal.com at 02:12am on 2006-03-04
Here from metaquotes, as I was wondering what on earth isosceles triangles had to do with drug inserts. I believe what you're seeing is a common way of denoting the orientation of the atoms hanging off the benzene ring. Anything that's attached via a simple straight line is in the plane of the page. Things with a solid black triangle are coming out the front, i.e., towards you as you look at the molecule. The ones that are denoted by the banded triangles are going out the back, i.e., away from you. In organic chemistry, the orientation is everything. For instance, one orientation of thalidomide is beneficial (prevents morning sickness); the other is very much not (causes extremely severe birth defects).

According to Wikipedia, this particular projection is called the Natta projection (http://en.wikipedia.org/wiki/Natta_projection). Other common ones include the Newman projection (http://en.wikipedia.org/wiki/Newman_projection) and the Fischer projection (http://en.wikipedia.org/wiki/Fischer_projection).
 
posted by [identity profile] dglenn.livejournal.com at 06:47pm on 2006-03-04
Ah! Thank you, and that makes a great deal of sense. I knew that isomers, even mere stereoisomers, mattered in biology, but it hadn't occurred to me that I was looking at a projection -- I thought there was maybe some new kind of bond I hadn't learned about in 11th grade or something. I'm relieved. Now that it's been explained, it seems nearly obvious (and, looking at the diagram of Topamax again, quite readable once one knows -- I can actually convince my brain to reinterpret the diagram as a three-dimensional image if I defocus my eyes a smidgen, which I didn't expect to happen so quickly).

Now off to Wikipedia to familiarize myself with the others so they won't seem so mysterious when I run across them.

Again, thanks.

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